Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: A case-controlled study (SIGNIFY)
| Autor: | Lucy Side, Emma Brown, Alexander Dias, Lauren Limb, Helen Hanson, Anthony Chamberlain, Sarah Benafif, Jeanette Rothwell, D. Gareth Evans, S. Aslam Sohaib, Rosalind A. Eeles, Jennifer Pope, Sibel Saya, Lisa Walker, Natalie Taylor, Richard W. Whitehouse, Diana Eccles, Christos Mikropoulos, Julian Barwell, Elizabeth Page, Martin O. Leach, Elizabeth Bancroft, Sarah Thomas, Balashanmugam Rajashanker, Dow-Mu Koh, Alan Donaldson, Susan Shanley, Jackie Cook, David J. Gallagher, Fiona J. Gilbert, Louise Izatt, Leslie G. Walker, Vicki Wiles |
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| Přispěvatelé: | Bancroft, Elizabeth K [0000-0002-5482-5660], Saya, Sibel [0000-0002-4796-6852], Eccles, Diana M [0000-0002-9935-3169], Evans, D Gareth [0000-0002-8482-5784], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
psychosocial Male Li-Fraumeni Syndrome TP53 gene pathogenic variant 0302 clinical medicine Risk Factors Neoplasms Whole Body Imaging Young adult Genetics (clinical) media_common education.field_of_study Middle Aged Magnetic Resonance Imaging 030220 oncology & carcinogenesis Cohort Screening Female Worry Psychosocial MRI Adult medicine.medical_specialty Heterozygote media_common.quotation_subject Population case controlled study Case controlled study Stress 03 medical and health sciences Young Adult Breast cancer Internal medicine Genetics medicine Cancer Genetics Humans Genetic Predisposition to Disease education Germ-Line Mutation business.industry Case-control study Cancer medicine.disease 030104 developmental biology Tumor Suppressor Protein p53 business |
| Zdroj: | Journal of Medical Genetics Bancroft, E K, Saya, S, Brown, E, Thomas, S, Taylor, N, Rothwell, J, Pope, J, Chamberlain, A, Page, E, Benafif, S, Hanson, H, Dias, A, Mikropoulos, C, Izatt, L, Side, L, Walker, L, Donaldson, A, Cook, J A, Barwell, J, Wiles, V, Limb, L, Eccles, D M, Leach, M O, Shanley, S, Gilbert, F J, Gallagher, D, Rajashanker, B, Whitehouse, R W, Koh, D-M, Sohaib, S A, Evans, D G, Eeles, R A & Walker, L G 2019, ' Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers : a case-controlled study (SIGNIFY) ', Journal of Medical Genetics . https://doi.org/10.1136/jmedgenet-2019-106407 |
| Popis: | BackgroundGermline TP53 gene pathogenic variants (pv) cause a very high lifetime risk of developing cancer, almost 100% for women and 75% for men. In the UK, annual MRI breast screening is recommended for female TP53 pv carriers. The SIGNIFY study (Magnetic Resonance Imaging screening in Li Fraumeni syndrome: An exploratory whole body MRI) study reported outcomes of whole-body MRI (WB-MRI) in a cohort of 44 TP53 pv carriers and 44 matched population controls. The results supported the use of a baseline WB-MRI screen in all adult TP53 pv carriers. Here we report the acceptability of WB-MRI screening and effects on psychosocial functioning and health-related quality of life in the short and medium terms.MethodsPsychosocial and other assessments were carried out at study enrolment, immediately before MRI, before and after MRI results, and at 12, 26 and 52 weeks’ follow-up.ResultsWB-MRI was found to be acceptable with high levels of satisfaction and low levels of psychological morbidity throughout. Although their mean levels of cancer worry were not high, carriers had significantly more cancer worry at most time-points than controls. They also reported significantly more clinically significant intrusive and avoidant thoughts about cancer than controls at all time-points. There were no clinically significant adverse psychosocial outcomes in either carriers with a history of cancer or in those requiring further investigations.ConclusionWB-MRI screening can be implemented in TP53 pv carriers without adverse psychosocial outcomes in the short and medium terms. A previous cancer diagnosis may predict a better psychosocial outcome. Some carriers seriously underestimate their risk of cancer. Carriers of pv should have access to a clinician to help them develop adaptive strategies to cope with cancer-related concerns and respond to clinically significant depression and/or anxiety. |
| Databáze: | OpenAIRE |
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