Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment
| Autor: | Belén Brie, Agustina Roldan-Deamicis, Gabriela A. Balogh, Diego Aguilera Braico |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Maitake Pro4X
0301 basic medicine Oncology medicine.medical_specialty Otras Ciencias Biológicas medicine.medical_treatment Pharmacology Malignancy General Biochemistry Genetics and Molecular Biology Ciencias Biológicas purl.org/becyt/ford/1 [https] 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer BREAST CANCER Internal medicine CANCER DE MAMA medicine QUIMIOTERAPIA purl.org/becyt/ford/1.6 [https] Adverse effect Chemotherapy business.industry Cancer CHEMOTHERAPY medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell SURVIVAL Hormonal therapy MAITAKE business CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Biology and Medicine. 201, 9(3) Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA |
| ISSN: | 0974-8369 |
| DOI: | 10.4172/0974-8369.1000394 |
| Popis: | Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment. Fil: Aguilera Braico, Diego Máximo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Brie, Belen. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|