Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential
| Autor: | Irma Virant-Klun, Edo Dzafic, Martin Stimpfel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Homeobox protein NANOG
endocrine system Cell type medicine.medical_specialty Review Fertilization in Vitro Primary Ovarian Insufficiency Biology Stem cell marker Growing Follicle Internal medicine Genetics medicine Humans Ovarian follicle Telomerase Genetics (clinical) Granulosa Cells Stem Cells Transdifferentiation Obstetrics and Gynecology General Medicine Cell biology medicine.anatomical_structure Endocrinology Reproductive Medicine Cell Transdifferentiation Oocytes Female sense organs Stem cell Biomarkers hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 30:1255-1261 |
| ISSN: | 1573-7330 1058-0468 |
| Popis: | The ovarian follicle represents the basic functional unit of the ovary and consists of an oocyte, which is surrounded by granulosa cells (GCs). GCs play an important role in the growth and development of the follicle. They are subject to increased attention since it has recently been shown that the subpopulation of GCs within the growing follicle possesses exceptionally plasticity showing stem cell characteristics. In assisted reproduction programs, oocytes are retrieved from patients together with GCs, which are currently discarded daily, but could be an interesting subject to be researched and potentially used in regenerative medicine in the future. Isolated GCs expressed stem cell markers such as OCT-4, NANOG and SOX-2, showed high telomerase activity, and were in vitro differentiated into other cell types, otherwise not present within ovarian follicles. Recently another phenomenon demonstrated in GCs is transdifferentiation, which could explain many ovarian pathological conditions. Possible applications in regenerative medicine are also given. |
| Databáze: | OpenAIRE |
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