Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention

Autor: Tanja Milicic, Ljiljana Lukic, Sandra Singh, Aleksandra Jotic, Ljubica Stošić, M. Zamaklar, Nebojsa Lalic, N. Rajkovic, Katarina Lalic
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Leptin
Male
obesity
Health
Toxicology and Mutagenesis
lcsh:Medicine
Type 2 diabetes
030204 cardiovascular system & hematology
Overweight
0302 clinical medicine
Risk Factors
cardiovascular prevention
diabetes
adipocytokines
inflammatory markers
Insulin
Resistin
Middle Aged
3. Good health
C-Reactive Protein
Cardiovascular Diseases
Female
Adiponectin
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Adipokine
030209 endocrinology & metabolism
Article
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Humans
Aged
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
Public Health
Environmental and Occupational Health
nutritional and metabolic diseases
medicine.disease
Obesity
Endocrinology
Diabetes Mellitus
Type 2
business
Biomarkers
Zdroj: International Journal of Environmental Research and Public Health, Vol 11, Iss 4, Pp 4049-4065 (2014)
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health; Volume 11; Issue 4; Pages: 4049-4065
ISSN: 1660-4601
Popis: This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m2) (group A), 21 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin.
Databáze: OpenAIRE
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