Effect of marathon and ultra-marathon on inflammation and iron homeostasis
| Autor: | Maximilian Tscharre, Christoph C Kaufmann, Irena Vujasin, Matthias K. Freynhofer, Ioannis Tentzeris, Kurt Huber, Paul M Haller, Edita Piackova, Bernhard Jäger, Mona Kassem, Johann Wojta, Claudia Wegberger |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils Iron education Physical Therapy Sports Therapy and Rehabilitation Inflammation Marathon Running 030204 cardiovascular system & hematology Ultra marathon Monocytes 03 medical and health sciences 0302 clinical medicine Iron homeostasis Paired samples Endurance training Internal medicine medicine Leukocytes Homeostasis Humans Orthopedics and Sports Medicine Prospective Studies Muscle Skeletal biology medicine.diagnostic_test Transferrin saturation business.industry 030229 sport sciences Ferritin Endocrinology C-Reactive Protein Ferritins biology.protein Serum iron Female medicine.symptom business Energy Metabolism human activities Biomarkers |
| Zdroj: | Scandinavian journal of medicinescience in sportsREFERENCES. 31(3) |
| ISSN: | 1600-0838 |
| Popis: | The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance. |
| Databáze: | OpenAIRE |
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