Trihexyphenidyl in young children with dystonic cerebral palsy: A single arm study

Autor: Lavanya Rajkumar, Abhinaya Ventatakrishnan, Smitha Sairam, Megha Khosla, Ritu Khanna, Biswajit Das, Devendra Mishra, Monica Juneja
Rok vydání: 2022
Předmět:
Zdroj: Journal of pediatric rehabilitation medicine.
ISSN: 1875-8894
Popis: PURPOSE: The incidence of dystonic cerebral palsy causing significant morbidity is on the rise. There is a paucity of evidence for the management of dystonia in children. METHODS: Forty-one children aged 6 months-5 years with predominantly dystonic cerebral palsy were started on a predetermined protocol of trihexyphenidyl (0.25–0.52 mg/kg) and followed up at 3, 6 and 12 weeks. Dystonia severity, motor function and developmental age at baseline and 12 weeks were compared using the Global Dystonia Scale (GDS), the Gross Motor Function Measure (GMFM), and Fine Motor/Perceptual Subscale of the Early Developmental Profile-2. Thirty-four children completed the entire 12 weeks of intervention. RESULTS: The mean age of participants was 25±11 months. A significant decrease in median total dystonia scores on the GDS was observed post-intervention (74.5 to 59, p
Databáze: OpenAIRE