Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease
| Autor: | Anupriya Gangal, Issam A. Awad, Robert Shenkar, Dean Y. Li, Romuald Girard, Michael Jesselson, Maged D Fam, Changbin Shi, Omaditya Khanna, Hussein A. Zeineddine, Lingjiao Zhang, Christopher C. Gibson, James K. Liao, Meijing Wu, Kevin J. Whitehead |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Hemangioma Cavernous Central Nervous System Clinical Biochemistry Inflammation Disease 030204 cardiovascular system & hematology Gastroenterology Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Drug Discovery Vitamin D and neurology Leukocytes Medicine Humans Vitamin D Demography rho-Associated Kinases business.industry Cholesterol Biochemistry (medical) Cholesterol HDL Peripheral plasma Middle Aged Endocrinology C-Reactive Protein chemistry Non hdl cholesterol Acute Disease Chronic Disease Biomarker (medicine) Female medicine.symptom business 030217 neurology & neurosurgery Biomarkers Research Article |
| Zdroj: | Biomarkers in medicine. 10(3) |
| ISSN: | 1752-0371 |
| Popis: | Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case–control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease. |
| Databáze: | OpenAIRE |
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