T cells specific for the triggering virus infiltrate the eye in patients with herpes simplex virus-mediated acute retinal necrosis
| Autor: | G. Seerp Baarsma, Albert D. M. E. Osterhaus, E.J. Feron, Georges M. G. M. Verjans, Allegonda Van der Lelij, José G. C. Cornelissen, Marlinda E. M. Dings |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Herpesvirus 3 Human viruses T cell Receptors Antigen T-Cell alpha-beta T-Lymphocytes Eye Infections Viral Herpesvirus 1 Human Biology medicine.disease_cause Eye Virus Herpesviridae Aqueous Humor Antigen medicine Immunology and Allergy Humans Antigens Viral Cells Cultured Aged Varicella zoster virus Herpes Simplex Retinal Necrosis Syndrome Acute Middle Aged medicine.disease Virology Infectious Diseases Herpes simplex virus medicine.anatomical_structure Immunology Herpes Zoster Ophthalmicus Cytokines Female Acute retinal necrosis CD8 Cell Division |
| Zdroj: | The Journal of infectious diseases. 178(1) |
| ISSN: | 0022-1899 |
| Popis: | Acute retinal necrosis (ARN) is a rare, potentially blinding retinal disease resulting from ocular infections with herpes simplex virus (HSV) or varicella-zoster virus (VZV). To determine the antigen specificity and functional characteristics of ocular infiltrating T cells in ARN, T cells were isolated and expanded nonspecifically from intraocular fluid (IOF) samples from 2 patients with HSV-1 ‐ and 3 with VZV-mediated ARN. HSV-specific T cell reactivity could be detected only in the IOFderived T cell lines (TCLs) of the 2 patients with HSV-mediated ARN. These TCLs consisted of both HSV type-common and type-specific CD4 / and CD8 / T cell clones (TCCs) with differential T cell receptor usage. Irrespective of their phenotype, the TCCs were cytolytic and secreted interferon-g, tumor necrosis factor-a, interleukin-4, and interleukin-5. In both patients, the antigen specificity of a substantial number of HSV-1 ‐ specific TCCs could be mapped toC0.67 ‐ 0.73 HSV1 map units. The data presented suggest the contribution of T cells, specific for the triggering virus, to the pathogenesis of ARN. Acute retinal necrosis (ARN) in humans is a retinal disease cytopathic effect of the virus on infected retinal cells, the immune response directed against the inciting virus has been caused by an acute and rapidly progressing retinal inflammation |
| Databáze: | OpenAIRE |
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