Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica
| Autor: | Bonaventure T. Ngadjui, Jacobus Nicolaas Eloff, Jean Paul Dzoyem, Armelle Tontsa Tsamo, Raduis Melong, Deccaux G.W.F. Kapche, Lyndy Joy McGaw, Timoleon Maffo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant Free radical scavenging Cytotoxicity Endophytic fungi medicine.medical_treatment 030106 microbiology Epicoccum nigrum Bacillus cereus lcsh:RS1-441 Plant use of endophytic fungi in defense Microbiology lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound Pharmacology Toxicology and Pharmaceutics(all) medicine General Pharmacology Toxicology and Pharmaceutics biology Traditional medicine biology.organism_classification Antimicrobial Beauvericin 030104 developmental biology chemistry Antibacterial activity |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 27, Iss 2, Pp 251-253 Revista Brasileira de Farmacognosia, Volume: 27, Issue: 2, Pages: 251-253, Published: APR 2017 Revista Brasileira de Farmacognosia, Vol 27, Iss 2, Pp 251-253 (2017) |
| ISSN: | 0102-695X |
| DOI: | 10.1016/j.bjp.2016.08.011 |
| Popis: | Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 μg/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50 values ranged from 40.42 to 86.56 μg/ml, 31.87 to 86.57 μg/ml and 21.59 to 67.27 μg/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections. Keywords: Antimicrobial, Free radical scavenging, Cytotoxicity, Endophytic fungi, Epicoccum nigrum |
| Databáze: | OpenAIRE |
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