Evaluation of the trends and appropriateness of fluoroquinolone use in the outpatient treatment of acute uncomplicated cystitis at five family practice clinics
| Autor: | Alice E Barsoumian, Stephanie E. Giancola, Thomas F. Robinson, James K. Aden |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Psychological intervention Urinalysis Logistic regression 030226 pharmacology & pharmacy Antimicrobial Stewardship Young Adult 03 medical and health sciences 0302 clinical medicine Levofloxacin Internal medicine Cystitis Outpatients medicine Humans Pharmacology (medical) 030212 general & internal medicine Practice Patterns Physicians' Antibiotic use Pharmacology business.industry Retrospective cohort study Middle Aged Texas Anti-Bacterial Agents Ciprofloxacin Nitrofurantoin Female Family Practice business Fluoroquinolones medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 45:513-519 |
| ISSN: | 1365-2710 0269-4727 |
| DOI: | 10.1111/jcpt.13099 |
| Popis: | WHAT IS KNOWN AND OBJECTIVE Despite recommendations to avoid fluoroquinolones (FQs) as a first-line treatment for uncomplicated cystitis, recent data suggest that FQs remain widely prescribed. Therefore, the objectives of this study were to evaluate the appropriateness of empiric FQ use compared to nitrofurantoin for uncomplicated cystitis and to determine whether there are any trends or predictors of empiric FQ versus nitrofurantoin use for uncomplicated cystitis. METHODS This retrospective study included women ages 19-64 years who were seen at five family medicine clinics and were prescribed targeted antibiotics (nitrofurantoin, ciprofloxacin or levofloxacin) for uncomplicated cystitis. Charts were reviewed to collect data, including symptoms, comorbidities, allergies, creatinine clearance, recent antibiotic use and urine culture data. Appropriateness of empiric selection was determined based on national guidelines and local susceptibility data. RESULTS AND DISCUSSION A total of 677 patient encounters were screened for inclusion. Of those, 567 met the inclusion criteria: 395 nitrofurantoin and 172 FQs. Treatment was considered appropriate in 86.8% and 10.5% of cases that were prescribed nitrofurantoin and FQs, respectively (P |
| Databáze: | OpenAIRE |
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