Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients
| Autor: | Yongping Chen, Bangshuo Zhang, Chunhui Lang, Zhengjun Yi, Qingjie Yi, Jianglin Xiang, Lian Guo, Shibing Fan, Cailiang Gao, Jinglong Lv, Kaihu Xiao, Xianxiang Zhang, Qing Xiao, Suxin Wan, Mao Qiang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.disease_cause Gastroenterology 0302 clinical medicine COVID-19 Testing Lung Coronavirus Aged 80 and over Covid‐19 biology Hematology Middle Aged Interleukin 10 medicine.anatomical_structure 030220 oncology & carcinogenesis Disease Progression Female Coronavirus Infections Research Paper Adult medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Adolescent pulmonary inflammatory index Pneumonia Viral disease classification coronavirus infected disease 03 medical and health sciences Betacoronavirus Internal medicine medicine Humans Interleukin 6 Pandemics Aged lymphocyte subsets Cluster of differentiation business.industry Clinical Laboratory Techniques SARS-CoV-2 fungi COVID-19 Pneumonia medicine.disease cytokines biology.protein business CD8 030215 immunology |
| Zdroj: | British Journal of Haematology |
| ISSN: | 1365-2141 |
| Popis: | Summary We explored the relationships between lymphocyte subsets, cytokines, pulmonary inflammation index (PII) and disease evolution in patients with (corona virus disease 2019) COVID‐19. A total of 123 patients with COVID‐19 were divided into mild and severe groups. Lymphocyte subsets and cytokines were detected on the first day of hospital admission and lung computed tomography results were quantified by PII. Difference analysis and correlation analysis were performed on the two groups. A total of 102 mild and 21 severe patients were included in the analysis. There were significant differences in cluster of differentiation 4 (CD4+ T), cluster of differentiation 8 (CD8+ T), interleukin 6 (IL‐6), interleukin 10 (IL‐10) and PII between the two groups. There were significant positive correlations between CD4+ T and CD8+ T, IL‐6 and IL‐10 in the mild group (r 2 = 0·694, r 2 = 0·633, respectively; P |
| Databáze: | OpenAIRE |
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