Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus
| Autor: | Bradley J. Van Sickle, Jill H. Simmons, Randon Hall, Anna Spagnoli, Kate Ness, Miranda D Raines |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent endocrine system diseases medicine.medical_treatment Immunology Biochemistry Article Proinflammatory cytokine Internal medicine Diabetes mellitus medicine Immunology and Allergy Humans Interleukin 8 Insulin-Like Growth Factor I Molecular Biology Type 1 diabetes business.industry Growth factor Interleukin-8 Hematology medicine.disease Cytokine Endocrinology Diabetes Mellitus Type 1 Poor control Metabolic control analysis Female business |
| DOI: | 10.17615/4cfv-4n66 |
| Popis: | A dysregulated growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is well-recognized in children and adolescents with type 1 diabetes mellitus (T1DM). Decreased IGF-1 levels can also be found in chronic inflammatory diseases, while hyperglycemia promotes inflammatory cytokine production. Therefore, inflammatory cytokines may link poor metabolic control with GH/IGF-1 axis changes. This study examined the relationship between serum inflammatory cytokines and IGF-1 in adolescents (age 13-18) with TIDM in chronic poor (n=17) or favorable (n=19) glucose control. Poor control (PC) was defined asor=3, consistent HbA1C9% during the previous 2 years, while favorable control (FC) was consistent levels of HbA1C9%.HbA1C (FC: 7.5+/-0.6%; PC: 10.5+/-0.9%, p0.001) and interleukin (IL)-8 (FC: 3.7+/-4.0 pg/ml; PC: 7.4+/-4.3 pg/ml, p=0.01) were increased and IGF-1 (FC: 536.5+/-164.3 ng/ml; PC: 408.9+/-157.1 ng/ml, p=0.03) was decreased in patients with poor control compared to patients with favorable control. Moreover, IL-8 was inversely correlated with IGF-1 (r=-0.40, p=0.03) and positively correlated with HbA1C (r=0.36, p=0.03).In adolescents with T1DM and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis. |
| Databáze: | OpenAIRE |
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