Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives
| Autor: | Mahmut Ülger, Fatma Kaynak Onurdağ, Sevilay Akçay, Yasemin Dündar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Antifungal
antimycobacterial activity pyrido[3 4-d]pyridazine derivatives biology medicine.drug_class Stereochemistry pyrido[3 4-d]pyridazin-1(2H)-one Biological activity biology.organism_classification Antimycobacterial pyrido[3 4-d]pyridazin-4(3H)-one In vitro lcsh:Chemistry Pyridazine chemistry.chemical_compound lcsh:QD1-999 chemistry medicine General Earth and Planetary Sciences Bacteria General Environmental Science |
| Zdroj: | Acta Chimica Slovenica, Vol 65, Iss 4, Pp 932-938 (2018) |
| Popis: | In this study, new pyrido[3,4- d ]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl)pyrido[3,4- d ]pyridazin-4(3 H )-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4- d ]pyridazin-4(3 H )-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus. |
| Databáze: | OpenAIRE |
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