The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate
| Autor: | İbrahim Pirim, Hasan Dogan, Ayhan Tastekin, Mevlit Ikbal, Rahmi Ors |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.drug_class Health Toxicology and Mutagenesis Lymphocyte Chloral hydrate Sister chromatid exchange Pharmacology medicine.disease_cause Hypnotic Genetics medicine Humans Chloral Hydrate Lymphocytes Micronucleus Tests Mutagenicity Tests business.industry Infant Newborn Infant medicine.anatomical_structure Bromodeoxyuridine Sedative Cytogenetic Analysis Micronucleus test Female business Micronucleus Sister Chromatid Exchange Genotoxicity medicine.drug |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 564:159-164 |
| ISSN: | 1383-5718 |
| Popis: | Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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