HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis
| Autor: | Joachim Georgi, Ilka Senkpiehl, Martina Wedler, Jörg Steinmann, Matthias Marget, Dietrich Kabelitz, Stefan Jenisch |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
musculoskeletal diseases
Male Immunology Antigen presentation Peptide Peptides Cyclic Arthritis Rheumatoid Cohort Studies chemistry.chemical_compound Immunopathology medicine Citrulline HLA-DR4 Antigen Immunology and Allergy Humans skin and connective tissue diseases HLA-DRB1 Autoantibodies Autoimmune disease chemistry.chemical_classification biology business.industry General Medicine HLA-DR Antigens medicine.disease chemistry Rheumatoid arthritis biology.protein Female Antibody business Biomarkers HLA-DRB1 Chains |
| Zdroj: | International archives of allergy and immunology. 137(4) |
| ISSN: | 1018-2438 |
| Popis: | Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expression of anti-CCP correlates with the carriage of certain genes on the HLA-DRB1 locus. Our data reveal a highly significant association between anti-CCP and HLA-DR4, and a weaker but still significant association with HLA-DR1. HLA-DRB1*0401 is not a prerequisite for anti-CCP production, but if HLA-DRB1*0401 was present, 90% of our RA patients were anti-CCP positive. |
| Databáze: | OpenAIRE |
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