Small Bite-Angle P–OP Ligands for Asymmetric Hydroformylation and Hydrogenation

Autor:	Jordi Benet-Buchholz, Anton Vidal-Ferran, Héctor Fernández-Pérez
Rok vydání:	2013
Předmět:	Chemistry Stereochemistry Organic Chemistry Heteroatom Carbonyl reduction Stereoselectivity Physical and Theoretical Chemistry Phosphamide Bite angle Biochemistry Hydroformylation Catalysis Stereocenter
Zdroj:	Organic Letters. 15:3634-3637
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol401494x
Popis:	A series of small bite-angle phosphine-phosphite (P-OP) ligands have been synthesized by a two-step method. The key intermediate was prepared by an unprecedented asymmetric carbonyl reduction of a phosphamide using the CBS (Corey-Bakshi-Shibata) catalyst. The topology of these ligands (a configurationally stable stereogenic carbon with two heteroatom substituents) and their small bite-angle (created by the close proximity of the two ligating groups to the metal center) together provide a rigid asymmetric environment around this center, enabling high stereoselectivity in hydroformylations and hydrogenations of standard substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf708f4904195ebc1451f960c65b4a3 https://doi.org/10.1021/ol401494x Zobrazit plný text záznamu