Plasma calcitonin gene-related peptide decreases in chronic congestive heart failure
| Autor: | C. Landault, Grosgogeat Y, F. Belas, J. C. Legrand, Alain Carayon, H. Taquet, Philippe Lechat, Michel Komajda, O. Grenier |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Chronic congestive heart failure Sympathetic Nervous System Calcitonin Gene-Related Peptide Radioimmunoassay Peptide Calcitonin gene-related peptide Pathogenesis Norepinephrine Internal medicine Medicine Humans chemistry.chemical_classification Heart Failure business.industry Heart Plasma levels Middle Aged medicine.disease Pathophysiology Endocrinology chemistry Calcitonin Heart failure Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | European heart journal. 13(11) |
| ISSN: | 0195-668X |
| Popis: | To investigate the role of calcitonin gene-related peptide (CGRP) in cardiac failure, a sensitive and specific radioimmu-noassay was developed to study plasma levels of CGRP in 37 normal subjects and 41 patients with heart failure (HF). The mean plasma levels of CGRP were 294·3 pg . ml−1 (SEM: 41·4) in normal subjects and 121·2 pg . ml−1 (SEM: 21·2) in HF patients. The significant decrease observed in HF patients suggests that CGRP is involved in the pathogenesis of heart failure via a direct effect or via modulation of sympathetic nervous activity. |
| Databáze: | OpenAIRE |
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