| Popis: |
Additional file 2: Figure S2. Repopulation of microglia does not ameliorate Aβ pathology and neuritic damage in APP/PS1 female mice. Representative immunofluorescent 20× images of the subiculum in control versus PLX-repopulated group, showing Aβ plaque (6E10, red), microglia (Iba1, magenta), and neuritic damage (LAMP1, green) (A). There was no difference in the total area (B), size (C) and number (D) of plaques between the control and PLX-treated groups. The ratio of plaque-associated neuritic damage to plaque load was similar between the control and PLX-repopulated group in CA1 but was significantly increased in the subiculum (E). Student’s t-test, *p < 0.05. Data are presented as mean ± SEM (n = 6). |
