An Escalating Dose Oral Gavage Study of 3β-Acetoxyandrost-5-ene-7,17-dione (7-oxo-DHEA-acetate) in Rhesus Monkeys
| Autor: | Charles E. Weeks, Susan M. Henwood, Henry A. Lardy |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Behavior Animal business.industry Visual examination Body Weight Biophysics Administration Oral Dehydroepiandrosterone Cell Biology 7-oxo-DHEA-acetate Body weight Macaca mulatta Biochemistry Oral gavage Anabolic Agents Endocrinology Internal medicine Animals Medicine Female Dosing business Molecular Biology |
| Zdroj: | Biochemical and Biophysical Research Communications. 254:124-126 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1998.9908 |
| Popis: | To test the effects of 7-oxo-dehydroepiandrosterone-3 acetate (hereafter 7-ODA) in Rhesus macaques the steroid was administered by oral gavage to two male and two female monkeys. Dose levels of 250, 500, and 1,000 mg/kg body weight (BW)/day were administered on days 1, 3, and 5 respectively, and 1,000 mg/kg on days 7 through 11. Each group received the dose in a volume of 10 ml/kg BW. All animals survived to the scheduled sacrifice on day 12. No adverse clinical effects of 7-ODA were observed at the 250 or 500 mg/kg doses. Females vomited on non-treatment days and all animals vomited on some days after being given the 1000 mg/kg dose. Excessive salivation was observed before or immediately after dosing on days 9 through 11. Appearance, behavior and body weights were not altered by the treatments. Visual examination of all body cavities, and macroscopic and microscopic examination of 42 different organs and tissues found no lesions or abnormalities. |
| Databáze: | OpenAIRE |
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