Blockade of different subtypes of α(1)-adrenoceptors produces opposite effect on heart chronotropy in newborn rats
| Autor: | L. I. Fashutdinov, N. I. Ziyatdinova, Timur Lvovich Zefirov, R. E. Dementieva |
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| Rok vydání: | 2013 |
| Předmět: |
Chronotropic
medicine.medical_specialty business.industry Increased heart rate General Medicine α1 adrenoceptor General Biochemistry Genetics and Molecular Biology Clonidine Piperazines Blockade Rats Heart Rhythm Dioxanes chemistry.chemical_compound Endocrinology chemistry Animals Newborn Chloroethylclonidine Heart Rate Internal medicine Receptors Adrenergic alpha-1 medicine Adrenergic alpha-1 Receptor Antagonists Animals business |
| Zdroj: | Bulletin of experimental biology and medicine. 154(2) |
| ISSN: | 1573-8221 |
| Popis: | We compared the effects of blockade of α(1A)-, α(1B)-, and α(1D)-subtypes of α(1)-adrenoceptors on the cardiac rhythm in newborn rats. Different responses of the heart were observed after blockade of several subtypes of α(1)-adrenoceptors. Administration of WB 4101, a selective blocker of α(1A)-adrenoceptors, increased heart rate, while blockade of α(1AD)-adrenoceptors with BMY 7378 decelerated of heart rhythm. Blockade of α(1B)-adrenoceptors with chloroethylclonidine produced no significant effects on heart chronotropy. |
| Databáze: | OpenAIRE |
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