Perfluoro carbon bromides as contrast media in radiography of the central nervous system. A preliminary experimental report
| Autor: | D. M. Long, F. Brahme, M. Sovak, H. Powell |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Central Nervous System
Pathology medicine.medical_specialty Radiography Central nervous system Contrast Media 030204 cardiovascular system & hematology Subarachnoid Space 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bromide medicine Animals Radiology Nuclear Medicine and imaging 030212 general & internal medicine Subarachnoid Pressure Fluorocarbons Radiological and Ultrasound Technology business.industry Neurotoxicity medicine.disease Spinal cord medicine.anatomical_structure chemistry Rabbits Subarachnoid space business Iophendylate |
| Zdroj: | Acta radiologica. Supplementum. 347 |
| ISSN: | 0365-5954 |
| Popis: | A preliminary investigation of the properties of perfluorooctyl bromide in the subarachnoid space revealed this compound to have suitable attenuation capacity and advantageous physical and biologic properties for demonstration of the brain and spinal cord. No acute or chronic neurotoxicity was encountered. Microscopy demonstrated evidence of chronic inflammatory changes subsequent to long term exposure to the compound. It was concluded that the medium was superior to iodophendylate in several respects and that it may provide an alternative to water-soluble contrast media. Perfluorohexyl bromide proved unsuitable for neuroradiologic use because of formation of excessive amounts of non-absorbable gas, leading to high subarachnoid pressure and severe neurologic deficits. |
| Databáze: | OpenAIRE |
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