Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome
| Autor: | Jean-Michel Livrozet, Philippe Vanhems, C. Trepo, Jacques Ritter, Jean-Louis Touraine, Don Smith, Laurent Cotte, Jean-Pierre Routy, Nicolas Voirin, D. Baratin, Patrice Andre, David A. Cooper |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Time Factors HIV Infections Early initiation Antiretroviral Therapy Highly Active Internal medicine medicine Humans Pharmacology (medical) Cd4 cell count business.industry Health Policy Optimal treatment Disease progression virus diseases Viral Load Antiretroviral therapy CD4 Lymphocyte Count Acute Retroviral Syndrome Infectious Diseases Immunology Disease Progression HIV-1 RNA Viral Female business Viral load |
| Zdroj: | HIV Medicine. 9:440-444 |
| ISSN: | 1468-1293 1464-2662 |
| DOI: | 10.1111/j.1468-1293.2008.00576.x |
| Popis: | Objectives The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV-RNA trends was studied over a 2-year follow-up period. Methods Four groups of HIV-infected patients stratified according to the time interval from ARS onset to HAART initiation and a control group of untreated patients were compared. Results The results indicated that the earlier the start of HAART, the faster was the rate of CD4 increase and HIV-RNA decrease. However, this difference did not seem to persist at 24 months. Conclusions The optimal treatment strategy for HIV-infected patients needs to be explored further. |
| Databáze: | OpenAIRE |
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