Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients

Autor:	Anne Toftgaard Pedersen, Jesper Kjaergaard, Christian Hassager, Martin Frydland, Jakob Hartvig Thomsen, Anika Klein, Henrik Schmidt, Jacob Eifer Møller, Sebastian Wiberg
Rok vydání:	2022
Předmět:	NEURON-SPECIFIC ENOLASE STATEMENT resuscitation CARE COUNCIL EUROPEAN-SOCIETY TARGETED TEMPERATURE MANAGEMENT Out of hospital cardiac arrest CARDIOPULMONARY-RESUSCITATION Double-Blind Method ROC Curve inflammation outcome PROGNOSTICATION REPERFUSION Humans Coma Cardiology and Cardiovascular Medicine PROCALCITONIN Biomarkers Out-of-Hospital Cardiac Arrest
Zdroj:	Pedersen, A T, Kjaergaard, J, Hassager, C, Frydland, M, Thomsen, J H, Klein, A, Schmidt, H, Moller, J E & Wiberg, S 2022, ' Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients ', Scandinavian Cardiovascular Journal, vol. 56, no. 1, pp. 85-90 . https://doi.org/10.1080/14017431.2022.2074093
ISSN:	1651-2006
DOI:	10.1080/14017431.2022.2074093
Popis:	Objectives: Prognostication after out-of-hospital cardiac arrest (OHCA) remains challenging. The inflammatory response after OHCA has been associated with increased mortality. This study investigates the associations and predictive value between inflammatory markers and outcome in resuscitated OHCA patients.Design: The study is based on post hoc analyses of a double-blind controlled trial, where resuscitated OHCA patients were randomized to receive either exenatide or placebo. Blood was analyzed for levels of inflammatory markers the day following admission. Primary endpoint was time to death for up to 180-days. Secondary endpoints included 180-day mortality and poor neurological outcome after 180-days, defined as a cerebral performance category (CPC) of 3 to 5.Results: Among 110 included patients we found significant associations between higher leucocyte quartile and increasing mortality in univariable analysis (OR 2.6 (95%CI 1.6-4.2), pConclusions: Total leucocyte count and neutrophil levels measured the first day following OHCA were significantly associated with 180-day all-cause mortality and may potentially act as early predictors of outcome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce92bdbc2e189d9b1594c71c5ce7382 https://pubmed.ncbi.nlm.nih.gov/35546563 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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