An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes
| Autor: | Margalit Bleiberg, Dan Turner, Israel Yust, Mordechai Fried, Boris Tartakovsky, Michael Hoffman |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
education.field_of_study
Lipopolysaccharide medicine.drug_class Lymphocyte CD14 Immunology Population Lipopolysaccharide Receptors Antibodies Monoclonal Biology Monoclonal antibody Molecular biology Monocytes chemistry.chemical_compound medicine.anatomical_structure chemistry Antigen medicine Immunology and Allergy Humans Lymphocytes Antigens Receptor education Intracellular |
| Zdroj: | Immunology letters. 85(1) |
| ISSN: | 0165-2478 |
| Popis: | CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals. |
| Databáze: | OpenAIRE |
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