Definitive Radiation Therapy for Moderately Advanced Laryngeal Cancer: Effects of Accelerated Hyperfractionation
| Autor: | Mitsuru Okubo, T. Nishikawa, Kiyoshi Nakamatsu, Izumi Tachibana, Ryuta Koike, Toru Shibata, Yasumasa Nishimura, Kazunori Mori, Shuichi Kanamori |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Mucositis Glottis Cancer Research medicine.medical_specialty medicine.medical_treatment Urology Dermatitis Disease-Free Survival Carcinoma medicine Esophagitis Humans Radiology Nuclear Medicine and imaging Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Aged 80 and over Subglottic Carcinoma Radiotherapy business.industry Dose fractionation Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Chemotherapy regimen Surgery Radiation therapy Treatment Outcome Oncology Female Dose Fractionation Radiation business Hyperfractionation |
| Zdroj: | Japanese Journal of Clinical Oncology. 40:944-948 |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/hyq078 |
| Popis: | Objective: The purpose of this retrospective study was to analyze the results of accelerated hyperfractionation for patients with modeletaly advanced (T2 and T3) laryngeal cancer. Methods: Between 1998 and 2007, 9 supraglottic carcinomas (6 T2N0M0, 2 T2N2M0, 1 T3N0M0), 30 glottic carcinomas (25 T2N0M0, 5 T3N0M0), and 1 T2N0M0 subglottic carcinoma were treated with definitive radiotherapy using accelerated hyperfractionation without concurrent chemotherapy. The dose-fractionation for 35 patients was 72.8 Gy/56 fractions/5.6 weeks, and that for four patients treated between 1998 and 2001 was 72 Gy/60 fractions/6 weeks. One patient who had been treated with steroid therapy for systemic lupus erythematosus was treated by 67.8 Gy/44 fractions/4.4 weeks. Results: The local control and overall survival probabilities at 5 years for supraglottic carcinomas were 75% and 86%, respectively. Those for glottic carcinomas were 80% and 92%, respectively. The 5-year local control probabilities for T2 and T3 tumors were 85% and 56%, respectively. This excellent local control rate especially for T2 laryngeal carcinomas may be attributable to the effect of accelerated hyperfractionation. No late toxicities of grade 2 or more was noted among the 39 patients treated with 72.8 Gy/56 fractions or 72 Gy/60 fractions. Conclusion: Accelerated hyperfractionation of 72.8 Gy/56 fractions/5.6 weeks using 1.3 Gy/ fraction seems a safe and effective dose-fractionation for patients with moderately advanced laryngeal carcinomas. |
| Databáze: | OpenAIRE |
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