Are Vitamin D Deficiency and VDR Gene Polymorphisms Associated With Higher Blood Pressure Defined by the 2017 ACC/AHA in Postmenopausal Women?
| Autor: | Betânia Rodrigues dos Santos, Thaís Rasia da Silva, Poli Mara Spritzer, Karen Oppermann, Gislaine Casanova, Lucas Bandeira Marchesan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Postmenopausal women business.industry Endocrinology Diabetes and Metabolism medicine.disease Calcitriol receptor vitamin D deficiency Endocrinology Blood pressure Internal medicine medicine Reproductive Endocrinology Female Reproductive Health: Hormones Metabolism and Fertility business Gene AcademicSubjects/MED00250 |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/jendso/bvab048.1483 |
| Popis: | Postmenopausal status has been associated with an unfavorable phenotype tied to hormonal and metabolic changes, which collectively could contribute to an increased risk of cardiovascular disease. Vitamin D deficiency is frequent in postmenopausal women and may be linked to this phenotype and especially to an increased risk of developing hypertension. Vitamin D actions are modulated by the vitamin D receptor (VDR), and metabolic abnormalities have been associated with VDR gene variants in different populations. The aims of the present study were to assess the vitamin D levels, prevalence of vitamin D deficiency and genotypes of Fok-I, Bsm-I, Apa-I and Taq-I polymorphisms in the VDR gene and to determine whether vitamin D deficiency and VDR gene variants are associated with blood pressure levels and systemic arterial hypertension by the 2017 ACC/AHA definition in postmenopausal women. We conducted a cross-sectional study of biobanked blood samples from 339 postmenopausal women with no evidence of clinical disease. Blood pressure strata were defined according to the 2017 ACC/AHA cutoffs. Circulating 25(OH)D levels were considered deficient if |
| Databáze: | OpenAIRE |
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