A nanohybrid magnetic sensing probe for levofloxacin determination integrates porous graphene, selective polymer and graphene quantum dots
| Autor: | Noppanut Longnapa, Nutnicha Chansud, Opas Bunkoed |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Chemistry Graphene Polymers Clinical Biochemistry Molecularly imprinted polymer Pharmaceutical Science Nanoparticle Nanoprobe Nanotechnology Levofloxacin Fluorescence Analytical Chemistry law.invention Molecular Imprinting Sarafloxacin Quantum dot law Limit of Detection Drug Discovery Quantum Dots Graphite Porosity Spectroscopy |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 205 |
| ISSN: | 1873-264X |
| Popis: | A nanohybrid magnetic fluorescent sensing probe was designed and fabricated for ultrasensitive and selective determination of levofloxacin. The probe integrated porous graphene (PGr), magnetite (Fe3O4) nanoparticles and graphene quantum dots (GQDs) into selective molecularly imprinted polymer (MIP). The developed probe was sensitive, selective, and its binding ability enriched levofloxacin in complex samples. The fabrication strategy was evaluated to achieve the best performance and the synthesized sensing probe was characterized. In the best condition, the fluorescence emission of the probe was quenched linearly from 0.10 to 25.0 μg L-1 of levofloxacin and the limit of detection was 0.03 μg L-1. The quenching of fluorescence was not affected by the analog compounds ciprofloxacin, lomefloxacin, marbofloxacin and sarafloxacin. The imprinting factor of the developed nanohybrid sensing probe was 4.26. The developed probe was utilized to detect levofloxacin in milk and recoveries between 91.8 % and 100.5 % were achieved with RSDs |
| Databáze: | OpenAIRE |
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