Dissemination of blaOXA-370 is mediated by IncX plasmids and the Tn6435 transposon
| Autor: | Darlan Augusto da Costa Rocha, Jorge Luiz Mello Sampaio, Afonso Luis Barth, Juliana Coutinho Campos, Alexandre P. Zavascki, Suely C. F. Sampaio, Franciéli Pedrotti Rozales, Cibele Massotti Magagnin |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Transposable element Genetics PLASMÍDEOS biology 030106 microbiology Nucleic acid sequence General Medicine biology.organism_classification Enterobacteriaceae DNA sequencing 03 medical and health sciences Infectious Diseases Plasmid Composite transposon Gene Transposase |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | In Enterobacteriaceae, the blaOXA-48-like genes have been identified on plasmids in different regions of the world. The OXA-370 is a plasmid-encoded OXA-48-like enzyme reported in two distinct regions of Brazil. Recently, we demonstrate that the blaOXA-370 gene is disseminated among several Enterobacteriaceae species and clones, indicating a high potential for dissemination. In this work, we described for the first time the complete nucleotide sequence of six plasmids harboring the blaOXA-370 gene. Complete DNA sequencing using the Illumina platform and annotation of the plasmids showed that they belonged to incompatibility groups IncX and had in average 70 kbp. The blaOXA-370 gene is located in a composite transposon containing four genes encoding transposases, named Tn6435. In this study, highly similar plasmids were detected in different Enterobacteriaceae genera. |
| Databáze: | OpenAIRE |
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