Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection
| Autor: | Ellen Brinza, Chung-Lieh Hung, Mark D. Schluchter, Chun-Ho Yun, Cissy Kityo, Matthew Peters, Chris T. Longenecker, Grace A. McComsey, Jonathan Buggey, Grace Mirembe, Seunghee Margevicius |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Systole Cardiovascular Abnormalities Population Diastole Renal function HIV Infections 030312 virology Kidney Ventricular Dysfunction Left 03 medical and health sciences chemistry.chemical_compound Risk Factors Internal medicine medicine Albuminuria Humans Uganda Pharmacology (medical) Cystatin C Renal Insufficiency Chronic education 0303 health sciences education.field_of_study Creatinine business.industry Heart Odds ratio Middle Aged medicine.disease Confidence interval Infectious Diseases chemistry Antirheumatic Agents Cardiology Female Kidney Diseases medicine.symptom business Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 86:104-109 |
| ISSN: | 1525-4135 |
| Popis: | BACKGROUND People with HIV (PWH) are at an increased risk of both heart and kidney disease, but the relationship between kidney disease and cardiac structure and function in this population has not been well studied. In particular, whether the relationship between kidney disease and cardiac structure and function is stronger for PWH compared with uninfected controls is unknown. METHODS One hundred PWH on antiretroviral therapy were compared with 100 age-matched and sex-matched controls without HIV in Uganda. Multivariable regression models were used to examine associations between creatinine-based and cystatin C-based estimated glomerular filtration rate (eGFR), albumin-creatinine ratio, and echocardiographic measures of cardiac structure and function. RESULTS PWH had lower eGFRcr (β -7.486, 95% confidence interval: -13.868 to -1.104, P = 0.022) and a higher rate of albumin-creatinine ratio ≥30 (odds ratio 2.146, 95% confidence interval: 1.027 to 4.484, P = 0.042) after adjustment for traditional risk factors. eGFR was inversely associated with both left ventricular mass index and diastolic dysfunction in adjusted models but not with systolic function. Albuminuria was associated with more diastolic dysfunction among PWH but not controls (P for interaction = 0.046). The association of HIV with a higher left ventricular mass index (P = 0.005) was not substantially affected by adjusting for eGFRcr. CONCLUSION Among Ugandans, eGFR is associated with elevated LV mass and diastolic dysfunction. The association between albuminuria and diastolic dysfunction is particularly strong for PWH. |
| Databáze: | OpenAIRE |
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