Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis
| Autor: | Chuan-Feng Lv, Yu Zhang, Tie Hong, Zhen Yang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Berberine
medicine.medical_treatment Immunology Anti-Inflammatory Agents Administration Oral Pharmacology Toxicology Mice chemistry.chemical_compound medicine Animals Immunology and Allergy Colitis Dextran Sulfate Sodium Mice Inbred BALB C biology Dextran Sulfate General Medicine medicine.disease Malondialdehyde Disease Models Animal Cytokine chemistry Murine model Myeloperoxidase biology.protein Cytokines Female Hemoglobin |
| Zdroj: | Immunopharmacology and Immunotoxicology. 34:391-397 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.3109/08923973.2011.609887 |
| Popis: | The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Berberine, given orally at 40, 20, 10 mg/kg for 10 days, ameliorated all the supposed inflammatory symptoms of the induced colitis, such as body weightloss, blood hemoglobin reduction, high myeloperoxidase levels, and malondialdehyde content-inflamed mucosa. Furthermore, the cytokine production of splenic lymphocytes was analyzed. The results showed the IFN-γ and IL-12 were increased, but IL-4 and IL-10 were decreased in DSS-induced colitis,when those were compared with the normal control. But the administration of berberine to DSS-induced colitis mice showed lower production of IFN-γ and IL-12 and higher production of IL-4 and IL-10 than the DSS-induced colitis mice. The results suggest that the protective effects of berberine against the DSS-induced colitis may be associated with the regulation of cytokine production. |
| Databáze: | OpenAIRE |
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