Accelerated Aging versus Rejuvenation of the Immune System in Heterochronic Parabiosis
| Autor: | Alex Peregudov, Tatiana Orlova, Igor Artyuhov, Iryna Pishel, Gennadij Butenko, Dmytro Shytikov |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging Time Factors Parabiosis T-Lymphocytes Population Spleen Thymus Gland CD8-Positive T-Lymphocytes Biology Mice Immune system Phagocytosis medicine Animals Rejuvenation education Cell Proliferation education.field_of_study Aging Premature Flow Cytometry Hematopoietic Stem Cells Disease Models Animal Haematopoiesis Hyaluronan Receptors medicine.anatomical_structure Immune System Immunology Female Geriatrics and Gerontology Stem cell CD8 Hormone |
| Zdroj: | Rejuvenation Research. 15:239-248 |
| ISSN: | 1557-8577 1549-1684 |
| Popis: | The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, and others. Our investigations of heterochronic parabiosis have shown that benefits of a young immune system, e.g., actively working thymus and regular migration of young hematopoietic stem cells between parabiotic partners, appeared unable to restore the immune system of the old partner. At the same time, we have established a progressive immune impairment in the young heterochronic partners. The mechanism of age changes in the immune system in this model, which may lead to reduced life expectancy, has not been fully understood. The first age-related manifestation in the young partners observed 3 weeks after the surgery was a dramatic increase of CD8(+)44(+) cells population in the spleen. A detailed analysis of further changes revealed a progressive decline of most immunological functions observable for up to 3 months after the surgery. This article reviews possible mechanisms of induction of age-related changes in the immune system of young heterochronic partners. The data obtained suggest the existence of certain factors in the old organisms that trigger aging, thus preventing the rejuvenation process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|