The Airway Longitudinal Elastic Fiber Network and Mucosal Folding in Patients with Asthma
| Autor: | Steven F. Perry, Alan James, John C. Butt, Artee Karkhanis, Francis H. Y. Green, Salima Harji, N. Carroll |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Bronchi Critical Care and Intensive Care Medicine medicine Humans In patient Asthma Bronchus Mucous Membrane business.industry Smoking Respiratory disease Histology Fibroblasts respiratory system Elastic Tissue medicine.disease respiratory tract diseases medicine.anatomical_structure Female Collagen business Airway Myofibroblast Elastic fiber |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 161:244-248 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.161.1.9805005 |
| Popis: | A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds. |
| Databáze: | OpenAIRE |
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