Development of a matrix-based technology platform for the high throughput analysis of 3D cell cultures

Autor: Rimann, Markus, Bono, Epifania, Picenoni, Armin, Felley-Bosco, Emanuela, Meyer, Andreas, Pelleaux, René, Hund, Corinna
Jazyk: angličtina
Rok vydání: 2017
Předmět:
DOI: 10.21256/zhaw-3588
Popis: The screening of large cell libraries is an important process in pharmaceutical discovery and R&D, e.g. to define drug targets or develop effective medicines. The goal of this project is the implementation of a screening platform based on 3D cultivation of primary human mesothelioma cells encapsulated in alginate hydrogels. To this end, new hydrogel compositions will be designed, tested and finally utilized in the Nanoliter Reactor (NLR) cultivation system that enables high throughput analysis of 3D cell cultures.
Databáze: OpenAIRE