Extracellular vesicles in airway homeostasis and pathophysiology
| Autor: | Domenico Michele Modica, Stefano Burgio, Fabio Bucchieri, Alessandro Pitruzzella, Alberto Fucarino, Maria Concetta Zarcone, Francesco Cappello |
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| Přispěvatelé: | Fucarino A., Pitruzzella A., Burgio S., Zarcone M.C., Modica D.M., Cappello F., Bucchieri F. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
Cell type nanovesicles QH301-705.5 QC1-999 Asthma Chronic obstructive pulmonary disease COPD Epithelial–mesenchymal trophic unit Exosomes Microbiota Muco-microbiotic layer nanovesicles Outer membrane vesicles Biology chronic obstructive pulmonary disease Pathogenesis medicine COPD General Materials Science Biology (General) QD1-999 Instrumentation Asthma Fluid Flow and Transfer Processes Settore BIO/16 - Anatomia Umana Physics Process Chemistry and Technology General Engineering asthma Engineering (General). Civil engineering (General) medicine.disease muco-microbiotic layer Microvesicles Pathophysiology respiratory tract diseases Computer Science Applications Chemistry epithelial–mesenchymal trophic unit Immunology TA1-2040 Airway Homeostasis |
| Zdroj: | Applied Sciences, Vol 11, Iss 9933, p 9933 (2021) |
| Popis: | The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here. |
| Databáze: | OpenAIRE |
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