The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment
| Autor: | JW Paterson, C S May, R Ssendagire, ME Pickup |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.drug_class Administration Oral Biological Availability Pharmacology Ephedrine hydrochloride Theophylline Pharmacokinetics medicine Humans Asthmatic patient Pharmacology (medical) Ephedrine business.industry Drug Tolerance Plasma levels Middle Aged Asthma Barbiturate Phenobarbital Anesthesia Pharmacodynamics Drug Therapy Combination Female business Half-Life Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 3:123-134 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1976.tb00579.x |
| Popis: | 1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes. |
| Databáze: | OpenAIRE |
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