Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
| Autor: | Paul Ruchhoeft, Tim Sherlock, Richard C. Willson, Steven N. Ivers, Stephan A. Baranov, Katerina Kourentzi, Kirill V. Larin |
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| Rok vydání: | 2010 |
| Předmět: |
ocis:(280.4788) Optical sensing and sensors
Materials science medicine.diagnostic_test ocis:(170.4580) Optical diagnostics for medicine 010401 analytical chemistry Nanotechnology Magnetic resonance imaging Novel Light Sources Optics and Detectors Biological tissue ocis:(110.4500) Optical coherence tomography 01 natural sciences Reflectivity Atomic and Molecular Physics and Optics Retroreflector 0104 chemical sciences 010309 optics Whole milk Optical coherence tomography Porcine tissue 0103 physical sciences ocis:(170.4500) Optical coherence tomography medicine Biosensor Biotechnology Biomedical engineering |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.1.000367 |
| Popis: | A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue. |
| Databáze: | OpenAIRE |
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