Extent of human immunodeficiency virus type 1 drug resistance as a predictor of virological failure after genotype-guided treatment switch
| Autor: | Manuela Uberti, Angela Vivarelli, Francesco Esperti, Maurizio Zazzi, Marina Polidori, D. Dionisio |
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| Předmět: |
Adult
Male Microbiology (medical) Oncology medicine.medical_specialty Genotype Drug resistance Logistic regression Virus Acquired immunodeficiency syndrome (AIDS) Risk Factors Antiretroviral Therapy Highly Active Internal medicine medicine Humans Treatment Failure Sida Acquired Immunodeficiency Syndrome Analysis of Variance biology business.industry Drug Resistance Microbial Middle Aged medicine.disease biology.organism_classification Regimen Logistic Models Infectious Diseases Mutation Immunology Lentivirus HIV-1 Female Viral disease business Follow-Up Studies |
| Zdroj: | Università degli Studi di Siena-IRIS |
| Popis: | Little is known about factors involved in virological response to treatment changes guided by genotyping in patients whose highly active antiretroviral therapy (HAART) fails. A 12-month observational study was conducted of 45 patients infected with human immunodeficiency virus (HIV)-1, who underwent a new genotype-guided HAART regimen following virological treatment failure. Logistic regression models were used to define factors predictive of virological response to genotype-assisted treatment switches. Virological response was defined as achievement of a level of plasma HIV-1 RNA |
| Databáze: | OpenAIRE |
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