Serum prognostic indicators in experimental Bacteroides peritonitis
| Autor: | Robert J. Sharbaugh, William M. Rambo |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics Peritonitis Hemolytic Complement chemistry.chemical_compound Dogs Antibiotic therapy Serum lysozyme Medicine Animals Therapeutic Irrigation biology business.industry Clindamycin Complement System Proteins biology.organism_classification medicine.disease Bacteroides Infections Prognosis Surgery chemistry Female Muramidase Bacteroides Lysozyme business |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 110(9) |
| ISSN: | 0004-0010 |
| Popis: | Serum lysozyme and hemolytic complement (CH 100 ) levels were measured in dogs with experimental Bacteroides peritonitis. The CH 100 levels showed little change in surviving animals. Nonsurvivors showed a moderate decrease in complement levels shortly after contamination. Both surviving and nonsurviving animals showed a slight initial decrease in lysozyme levels shortly after contamination. In surviving dogs this was followed by an increase to normal levels. In nonsurvivors, levels continued to increase, reaching a threefold magnification just prior to death. As a result of antibiotic therapy, CH 100 levels exhibited no major changes; however, dogs deprived of antibiotic showed noticeable and persistent increases in lysozyme levels while treated animals showed only a mild elevation in lysozyme levels. The changes in the level of serum lysozyme may be a good indicator of antibiotic efficacy and approaching death from Bacteroides peritonitis. |
| Databáze: | OpenAIRE |
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