Styrene maleic acid copolymer induces pores in biomembranes
| Autor: | Irep Gözen, Marcella Orwick Rydmark, Mikkel Christensen, Elif Senem Köksal, Aldo Jesorka, Ventsislav Yantchev, Ilayda Kantarci, Kiryl Kustanovich |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Maleic acid Vesicle Bilayer Maleates Phospholipid 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics SMA 01 natural sciences 0104 chemical sciences Styrene chemistry.chemical_compound Membrane Solubility chemistry Chemical engineering Copolymer Polystyrenes 0210 nano-technology Porosity Unilamellar Liposomes |
| ISSN: | 1744-683X |
| Popis: | We investigated the interactions between styrene-maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 Å, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores. |
| Databáze: | OpenAIRE |
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