| Autor: |
Robert G. Strickley, Yujin Wang, Jaclyn Hayes, Michael L. Mitchell, Jennifer R. Zhang, Michael O'neil Hanrahan Clarke, Liu Qi, Margaret Robinson, Weidong Zhong, Edward Doerffler, Megan Tessler, Gina Bahador, Lazerwith Scott E, Lee Chong, Mike Matles, Neeraj Tirunagari, Jianhong Wang, Bernard P. Murray, Morganelli Philip Anthony, Xubin Zheng, Eugene J. Eisenberg, Bing Lu, Guofeng Cheng, Eda Canales, Mertzman Michael E, William J. Watkins |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
ACS medicinal chemistry letters. 2(10) |
| ISSN: |
1948-5875 |
| Popis: |
A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of compounds. In addition, a simple new metric that may aid in the prediction of bioavailability for compounds with higher polar surface area is described (3*HBD-cLogP). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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