A novel inhibitor of mammalian collagenase
| Autor: | Norman H Grant, Peter Wei, Donald E Clark |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Tail
Thermolysin Angiotensin-Converting Enzyme Inhibitors Matrix metalloproteinase General Biochemistry Genetics and Molecular Biology Cell Line Substrate Specificity Tendons Non-competitive inhibition medicine Animals Humans Protease Inhibitors Trypsin Benzothiazoles Cysteine General Pharmacology Toxicology and Pharmaceutics Fibroblast Skin Clostridium biology Biological activity General Medicine Fibroblasts Molecular biology Acetylcysteine Rats Kinetics Microbial Collagenase medicine.anatomical_structure Biochemistry Enzyme inhibitor biology.protein Collagenase medicine.drug |
| Zdroj: | Life Sciences. 37:575-578 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(85)90471-0 |
| Popis: | N -[[[(5-chloro-2-benzothiazolyl) thiolphenyllacetyll- L -cysteine (WY-45, 368) is a potent inhibitor of human skin fibroblast collagenase. Kinetic data show that the inhibition is competitive, with a Ki of 3.5 μM. WY-45, 368 inhibits neither of two other metalloproteinases, thermolysin and angiotensin converting enzyme, nor does it inhibit clostridial collagenase--thus indicating specificity for mammalian collagenase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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