Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation
| Autor: | López-Medrano, F, Fernández-Ruiz, M, Silva, J T, Carver, P L, van Delden, C, Merino, E, Pérez-Saez, M J, Montero, M, Coussement, J, de Abreu Mazzolin, M, Cervera, C, Santos, L, Sabé, N, Scemla, A, Cordero, E, Cruzado-Vega, L, Martín-Moreno, P L, Len, Ó, Rudas, E, Ponce de León, A, Arriola, M, Lauzurica, R, David, M D, González-Rico, C, Henríquez-Palop, F, Fortún, J, Nucci, M, Manuel, O, Paño-Pardo, J R, Montejo, M, Vena, A, Sánchez-Sobrino, B, Mazuecos, A, Pascual, J, Horcajada, J P, Lecompte, T, Moreno, A, Carratalà, J, Blanes, M, Hernández, D, Hernández-Méndez, E A, Fariñas, M C, Perelló-Carrascosa, M, Muñoz, P, Andrés, A, Aguado, J M, Spanish Network for Research in Infectious Diseases (REIPI), Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), Study Group for Infections in Compromised Hosts (ESGICH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Swiss Transplant Cohort Study (STCS) |
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| Přispěvatelé: | Van Delden, Christian, Spanish Network for Research in Infectious Diseases (REIPI), Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), Study Group for Infections in Compromised Hosts (ESGICH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Swiss Transplant Cohort Study (STCS), Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Respiratory diseases Aspergil·losi Time Factors Trasplantament renal 030230 surgery Global Health Kidney transplantation 0302 clinical medicine skin and connective tissue diseases ddc:616 Invasive Pulmonary Aspergillosis case-control study kidney transplantation late invasive pulmonary aspergillosis risk factors Case-control study Late invasive pulmonary aspergillosis Risk factors Factors de risc en les malalties Kidney Transplantation/adverse effects Invasive Pulmonary Aspergillosis/etiology General Medicine Middle Aged Infectious Diseases Female Microbiology (medical) medicine.medical_specialty Tuberculosis Risk factors in diseases 030106 microbiology Pulmonary disease Ronyons -- Trasplantació Malalties de l'aparell respiratori 03 medical and health sciences Internal medicine medicine Aspergillosis Humans De novo malignancy Retrospective Studies business.industry Pulmons -- Malalties Invasive pulmonary aspergillosis bacterial infections and mycoses medicine.disease Kidney Transplantation respiratory tract diseases Surgery Global Health/statistics & numerical data Transplantation Pneumonia Case-Control Studies business |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Clinical Microbiology and Infection, Vol. 24, No 2 (2018) pp. 192-198 Clinical Microbiology and Infection r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol CLINICAL MICROBIOLOGY AND INFECTION r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante Clinical microbiology and infection, vol. 24, no. 2, pp. 192-198 r-FISABIO. Repositorio Institucional de Producción Científica r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe |
| ISSN: | 1198-743X |
| Popis: | To assess the risk factors for development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by centre and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease, and/or de novo malignancy. We identified 61 cases of late (>180 days after transplantation) IPA from 24 participating centres (accounting for 54.5% (61/112) of all cases included in the overall study). Most diagnoses (54.1% (33/61)) were established within the first 36 post-transplant months, although five cases occurred more than 10 years after transplantation. Overall mortality among cases was 47.5% (29/61). Compared with controls, cases were significantly older (p 0.010) and more likely to have pre-transplant chronic obstructive pulmonary disease (p 0.001) and a diagnosis of bloodstream infection (p 0.016) and IRE (p 180 days after transplantation) IPA from 24 participating centres (accounting for 54.5% (61/112) of all cases included in the overall study). Most diagnoses (54.1% (33/61)) were established within the first 36 post-transplant months, although five cases occurred more than 10 years after transplantation. Overall mortality among cases was 47.5% (29/61). Compared with controls, cases were significantly older (p 0.010) and more likely to have pre-transplant chronic obstructive pulmonary disease (p 0.001) and a diagnosis of bloodstream infection (p 0.016) and IRE (p More than half of IPA cases after KT occur beyond the sixth month, with some of them presenting very late. Late IPA entails a poor prognosis. We identified some risk factors that could help the clinician to delimit the subgroup of KT recipients at the highest risk for late IPA. |
| Databáze: | OpenAIRE |
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