Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: The impact of the experimental design

Autor: Eberhard D. Pracht, Frauke Zipp, Amgad Droby, Matteo Bastiani, Sergiu Groppa, Silvia De Santis, Pierre Kolber, Tony Stoecker, Alard Roebroeck
Přispěvatelé: European Research Council, Brain and Behavior Research Foundation, Federal Ministry of Education and Research (Germany), Netherlands Organization for Scientific Research, Vision, RS: FPN CN 1
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Time Factors
Ultra-high field MRI
Axonal pathology
Cohort Studies
0302 clinical medicine
Nuclear magnetic resonance
methods [Diffusion Magnetic Resonance Imaging]
Microstructure
NODDI
medicine.diagnostic_test
General Neuroscience
WATER DIFFUSION
medicine.anatomical_structure
Research Design
Kurtosis
Multi-shell diffusion MRI
Axonal degeneration
WHITE-MATTER
TENSOR
Adult
Materials science
therapy [Multiple Sclerosis]
Sensitivity and Specificity
White matter
Multiple sclerosis
03 medical and health sciences
Fractional anisotropy
Image Interpretation
Computer-Assisted
medicine
diagnostic imaging [Nerve Degeneration]
Journal Article
Humans
ddc:610
OPTIMIZATION
instrumentation [Diffusion Magnetic Resonance Imaging]
diagnostic imaging [Multiple Sclerosis]
Magnetic resonance imaging
QUANTIFICATION
medicine.disease
MODEL
PATHOLOGY
Diffusion Magnetic Resonance Imaging
030104 developmental biology
RESOLUTION
DENSITY
Nerve Degeneration
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Neuroscience, 403, 17-26. Elsevier Science
Neuroscience 403, 17-26 (2019). doi:10.1016/j.neuroscience.2018.03.048
Neuroscience
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 0306-4522
1873-7544
Popis: The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI) made available new tools to image axonal pathology non-invasively in vivo. These methods already showed greater sensitivity and specificity compared to conventional diffusion tensor-based metrics (e.g., fractional anisotropy), overcoming some of its limitations. While previous studies uncovered global and focal axonal degeneration in MS patients compared to healthy controls, here our aim is to investigate and compare different diffusion MRI acquisition protocols in their ability to highlight microstructural differences between MS and control tissue over several much used models. For comparison, we contrasted the ability of fractional anisotropy measurements to uncover differences between lesion, normal-appearing white matter (WM), gray matter and healthy tissue under the same imaging protocols. We show that: (1) focal and diffuse differences in several microstructural parameters are observed under clinical settings; (2) advanced models (CHARMED, DKI and NODDI) have increased specificity and sensitivity to neurodegeneration when compared to fractional anisotropy measurements; and (3) both high (3 T) and ultra-high fields (7 T) are viable options for imaging tissue change in MS lesions and normal appearing WM, while higher b-values are less beneficial under the tested short-time (10 min acquisition) conditions.
SDS is supported by a NARSAD Young Investigator Grant (Grant #25104) and by the European Research Council through a Marie Skłodowska-Curie Individual Fellowship (Grant #749506). MB is supported by the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013/ERC Grant Agreement #319456). This work was also supported by a grant from Federal Ministry for Education and Research (BMBF, KKNMS, project MSNetworks) to SG and FZ. AR is supported by Netherlands Organisation for Scientific Research through a VIDI grant (#14637).
Databáze: OpenAIRE
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