Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine
| Autor: | Nordestgaard, B.G., Langsted, A., Mora, S., Kolovou, G., Baum, H., Bruckert, E., Watts, G.F., Sypniewska, G., Wiklund, O., Boren, J., Chapman, M.J., Cobbaert, C., Descamps, O.S., Eckardstein, A. von, Kamstrup, P.R., Pulkki, K., Kronenberg, F., Remaley, A.T., Rifai, N., Ros, E., Langlois, M., EAS, European Federation Clinical Chem |
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| Přispěvatelé: | University of Zurich, Nordestgaard, Børge G |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Consensus Apolipoprotein B Clinical Biochemistry 610 Medicine & health Familial hypercholesterolemia 1308 Clinical Biochemistry 030204 cardiovascular system & hematology 2704 Biochemistry (medical) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine 540 Chemistry Plasma lipids medicine Humans 030212 general & internal medicine Societies Medical 10038 Institute of Clinical Chemistry biology medicine.diagnostic_test Clinical Laboratory Techniques Cholesterol Biochemistry (medical) Fasting Atherosclerosis medicine.disease Lipids Europe Endocrinology chemistry Chemistry Clinical biology.protein European atherosclerosis society lipids (amino acids peptides and proteins) Apolipoprotein A1 Lipid profile Lipoprotein |
| Zdroj: | Clinical Chemistry, 62(7), 930-946 |
| Popis: | AIMSTo critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.METHODS AND RESULTSExtensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1–6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) for triglycerides; −0.2 mmol/L (8 mg/dL) for total cholesterol; −0.2 mmol/L (8 mg/dL) for LDL cholesterol; +0.2 mmol/L (8 mg/dL) for calculated remnant cholesterol; −0.2 mmol/L (8 mg/dL) for calculated non-HDL cholesterol]; concentrations of HDL cholesterol, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) are not affected by fasting/non-fasting status. In addition, non-fasting and fasting concentrations vary similarly over time and are comparable in the prediction of cardiovascular disease. To improve patient compliance with lipid testing, we therefore recommend the routine use of non-fasting lipid profiles, whereas fasting sampling may be considered when non-fasting triglycerides are >5 mmol/L (440 mg/dL). For non-fasting samples, laboratory reports should flag abnormal concentrations as triglycerides ≥2 mmol/L (175 mg/dL), total cholesterol ≥5 mmol/L (190 mg/dL), LDL cholesterol ≥3 mmol/L (115 mg/dL), calculated remnant cholesterol ≥0.9 mmol/L (35 mg/dL), calculated non-HDL cholesterol ≥3.9 mmol/L (150 mg/dL), HDL cholesterol ≤1 mmol/L (40 mg/dL), apolipoprotein A1 ≤1.25 g/L (125 mg/dL), apolipoprotein B ≥1.0 g/L (100 mg/dL), and lipoprotein(a) ≥50 mg/dL (80th percentile); for fasting samples, abnormal concentrations correspond to triglycerides ≥1.7 mmol/L (150 mg/dL). Life-threatening concentrations require separate referral for the risk of pancreatitis when triglycerides are >10 mmol/L (880 mg/dL), for homozygous familial hypercholesterolemia when LDL cholesterol is >13 mmol/L (500 mg/dL), for heterozygous familial hypercholesterolemia when LDL cholesterol is >5 mmol/L (190 mg/dL), and for very high cardiovascular risk when lipoprotein(a) >150 mg/dL (99th percentile).CONCLUSIONSWe recommend that non-fasting blood samples be routinely used for the assessment of plasma lipid profiles. Laboratory reports should flag abnormal values on the basis of desirable concentration cutpoints. Non-fasting and fasting measurements should be complementary but not mutually exclusive. |
| Databáze: | OpenAIRE |
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