Relationship between milk fatty acid composition and the expression of lipogenic genes in the mammary gland of dairy cows
| Autor: | J. van Baal, R.M.A. Goselink, A.M. van Vuuren, M.A. Smits, L. Kruijt, Núria Mach |
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| Přispěvatelé: | Animal Breeding and Genomics Centre, Wageningen University and Research [Wageningen] (WUR), Wageningen University and Research Centre (WUR) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Peroxisome proliferator-activated receptor gamma
medicine.medical_specialty Animal Nutrition 030309 nutrition & dietetics [SDV]Life Sciences [q-bio] Mammary gland Biology lipid supplements 03 medical and health sciences Internal medicine Gene expression medicine lactating cows Fokkerij & Genomica Transcription factor 030304 developmental biology Regulator gene chemistry.chemical_classification 0303 health sciences General Veterinary Research Fatty acid food and beverages Lipid metabolism tissue Diervoeding stearoyl-coa desaturase Sterol regulatory element-binding protein medicine.anatomical_structure Endocrinology Biochemistry chemistry networks WIAS nutritional regulation Animal Science and Zoology protein Wageningen Livestock Research Animal Breeding & Genomics Onderzoek |
| Zdroj: | Livestock Science Livestock Science, Elsevier, 2013, 151 (1), pp.92-96. ⟨10.1016/j.livsci.2012.10.014⟩ Livestock Science, 151(1), 92-96 Livestock Science 151 (2013) 1 |
| ISSN: | 1871-1413 |
| Popis: | This study focussed on the complex regulation of lipid metabolism in the mammary gland of cows and the association between milk fatty acid (FA) profile and the expression of lipogenic genes in individual cows. Changes in FA profile were found to be accompanied by changes in the expression of regulatory genes related to a wide range of metabolic functions. Expression of most of key lipogenic genes and transcription factors such as peroxisome proliferator-activated receptor gamma (PPARG), and sterol regulatory element binding factor 1 (SREBP1) was mainly negatively correlated to the concentration of trans-FA and CLA isomers in milk. These correlations suggest that changes in ruminal lipid metabolism may result in modifications in the expression of lipid metabolism-related genes at mammary level. |
| Databáze: | OpenAIRE |
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