Treatment and Prognosis of Brain Metastases From Gynecological Cancers
| Autor: | Shiro Iraha, Makoto Hirakawa, Sadayuki Murayama, Wakana Tamaki, Yasumasa Kakinohana, Takafumi Toita, Yoichi Aoki, Morihiko Inamine, Yukihiro Tsuchida, Akio Hyodo, Yoshihiko Yoshii, Yutaka Nagai, Kazuhiko Ogawa, K. Kamiyama, Genki Adachi |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Genital Neoplasms Female medicine.medical_treatment Brain tumor Disease Adenocarcinoma medicine Humans Survival analysis Aged Retrospective Studies Ovarian Neoplasms Univariate analysis Brain Neoplasms business.industry Endometrial cancer Middle Aged Prognosis medicine.disease Combined Modality Therapy Survival Analysis Surgery Radiation therapy Uterine Neoplasms Carcinoma Squamous Cell Female Neurology (clinical) Ovarian cancer business Brain metastasis |
| Zdroj: | Neurologia medico-chirurgica. 48:57-63 |
| ISSN: | 1349-8029 0470-8105 |
| DOI: | 10.2176/nmc.48.57 |
| Popis: | Brain metastases from gynecological cancers were retrospectively investigated in 18 patients who were treated between 1985 and 2006. Six patients received surgical resection followed by radiotherapy, and 12 patients received only radiotherapy. The median survival for all patients was 4.1 months (range 0.7-48.2 months), and the actuarial survival rates were 11% at both 12 months and 24 months. Univariate analysis showed that treatment modality, extracranial disease status, total radiation dose, number of brain metastases, and Karnofsky performance status (KPS) all had statistically significant impacts on survival. Two patients survived for more than 2 years, and both had single brain metastasis, inactive extracranial disease, 90-100% KPS, and were treated with surgical resection followed by radiotherapy. Improvements in neurological symptoms were observed in 10 of the 12 patients treated with palliative radiotherapy, with median duration of 3.1 months (range 1.5-4.5 months). The prognoses for patients with brain metastases from gynecological cancers were generally poor, although selected patients may survive longer with intensive brain tumor treatment. Palliative radiotherapy was effective in improving the quality of the remaining life for patients with unfavorable prognoses. |
| Databáze: | OpenAIRE |
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