A stem cell journey in ophthalmology: From the bench to the clinic
| Autor: | Ingrid W. Caras, Abla A. Creasey, Lila R. Collins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty retina Regenerative Medicine Regenerative medicine clinical translation Limbal stem cell deficiency R5-920 Ophthalmology Retinitis pigmentosa Medicine Humans Neural/Progenitor Stem Cells Induced Pluripotent stem cells Fetal Stem Cells QH573-671 business.industry retinal pigmented epithelium Stem Cells Cell Biology General Medicine cellular therapy medicine.disease eye diseases Pluripotent Stem Cells sense organs Stem cell Cytology business Developmental Biology Perspectives Stem Cell Transplantation |
| Zdroj: | Stem Cells Translational Medicine Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1581-1587 (2021) |
| ISSN: | 2157-6580 2157-6564 |
| Popis: | Debilitating diseases of the eye represent a large unmet medical need potentially addressable with stem cell‐based approaches. Over the past decade, the California Institute for Regenerative Medicine (CIRM) has funded and supported the translation, from early research concepts to human trials, of therapeutic stem cell approaches for dry age‐related macular degeneration, retinitis pigmentosa, and limbal stem cell deficiency. This article chronicles CIRM's journey in the ophthalmology field and discusses some key challenges and questions that were addressed along the way as well as questions that remain. Cell‐based therapies comprised of or derived from stem/progenitor cells are being developed to treat debilitating eye diseases such as dry age‐related macular degeneration (AMD), retinitis pigmentosa (RP), and limbal stem cell deficiency (LSD). Shown are the routes of delivery and location within the eye of the specific cell therapies discussed in this article. Adapted from https://www.freepik.com/premium-vector/eye-anatomy-vector_760161.htm. |
| Databáze: | OpenAIRE |
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