Specific nature of cellular immune responses elicited by chimpanzees against HIV-1
Autor: | Ronald E. Bontrop, Jonathan L. Heeney, Sunita S. Balla-Jhagjhoorsingh, Vera J. P. Teeuwsen, Ernst J. Verschoor, Natasja G. de Groot |
---|---|
Rok vydání: | 2003 |
Předmět: |
CD4-Positive T-Lymphocytes
Pan troglodytes Immunology Population Simian Acquired Immunodeficiency Syndrome Human immunodeficiency virus (HIV) HIV Infections CD8-Positive T-Lymphocytes Biology medicine.disease_cause Interferon-gamma Immune system Acquired immunodeficiency syndrome (AIDS) medicine Animals Humans Immunology and Allergy education Pathogen education.field_of_study Transmission (medicine) Disease progression Histocompatibility Antigens Class II T-Lymphocytes Helper-Inducer General Medicine Viral Load medicine.disease Virology Ape Diseases Disease Models Animal Disease Progression HIV-1 RNA Viral Interleukin-4 T-Lymphocytes Cytotoxic |
Zdroj: | Human Immunology. 64:681-688 |
ISSN: | 0198-8859 |
Popis: | Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage of the human population, however, individuals have been identified who were infected for more than 20 years and have no evidence of disease progression. In contrast to most infected humans, almost all chimpanzees appear to be resistant to the pathologic effects caused by lentiviruses such as HIV-1. Here we review the characteristics of the HIV-1-specific cell-mediated immune responses mounted by chimpanzees, and we postulate the mechanisms that have evolved that facilitate their resistance to acquired immunodeficiency syndrome. |
Databáze: | OpenAIRE |
Externí odkaz: |