Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils ofSalvia species and their constituents
| Autor: | Edward J. Okello, Sergey U. Savelev, Elaine K. Perry |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Erythrocytes
Stereochemistry Salvia law.invention Incubation period Inhibitory Concentration 50 Alzheimer Disease law Humans Plant Oils Medicine Essential oil Butyrylcholinesterase Cholinesterase Pharmacology chemistry.chemical_classification Dose-Response Relationship Drug biology Traditional medicine business.industry SAGE Anti-Inflammatory Agents Non-Steroidal Plant Components Aerial biology.organism_classification Terpenoid Enzyme chemistry Acetylcholinesterase biology.protein Cholinesterase Inhibitors business Phytotherapy |
| Zdroj: | Phytotherapy Research. 18:315-324 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.1451 |
| Popis: | Extracts of Salvia (sage) species have been reported to have cholinergic activities relevant to the treatment of Alzheimer's disease. A lack of information on the inhibition of the enzyme butyrylcholinesterase, also considered to be a target in the treatment of the disease, prompted this in vitro investigation of the essential oils of S. fruticosa, S. lavandulaefolia, S. officinalis and S. officinalis var. purpurea for anti-butyrylcholinesterase activity. Dose-dependent inhibition of human cholinesterases by the extracts and constituents was determined using the method of Ellman. A time dependent increase in the inhibition of butyrylcholinesterase by the oils of S. fruticosa and S. officinalis var. purpurea was evident. IC50 values decreased from 0.15 ± 0.007 and 0.14 ± 0.007 mg/mL after 5 min to 0.035 ± 0.016 and 0.06 ± 0.018 mg/mL after 90 min incubation time respectively. The slow onset of inhibition of butyrylcholinesterase was also shown by individual constituents, such as 3-carene and β-pinene. Analyses of the chemical composition of the oils and anti-butyrylcholinesterase activity of their constituents revealed that none of the compounds tested would account for the total activity of the oils and that synergy is likely. Copyright © 2004 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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