Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Autor: Nina Suhartha Löwa, Priscilla S. Brunetto, Inès Mottas, Magdalena Priebe, Carole Bourquin, Sarah-Luise Abram, Nina Khanna, Anne-Kathrin Woischnig, Katharina M. Fromm, Jérôme Widmer
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Metal Nanoparticles
Pharmaceutical Science
Medicine (miscellaneous)
02 engineering and technology
Antibacterial effect
medicine.disease_cause
01 natural sciences
Silver nanoparticle
Mice
chemistry.chemical_compound
Silicon Dioxide/chemistry
General Materials Science
Cells
Cultured
ddc:615
Escherichia coli/drug effects
ddc:617
Absolute number
Metal Nanoparticles/chemistry
Silicon Dioxide
021001 nanoscience & nanotechnology
Antimicrobial
Anti-Bacterial Agents
3. Good health
Staphylococcus aureus
Dendritic Cells/drug effects/metabolism
Drug delivery
Molecular Medicine
0210 nano-technology
Silver
Materials science
Silicon dioxide
Staphylococcus aureus/drug effects
Biomedical Engineering
Bioengineering
Nanotechnology
Microbial Sensitivity Tests
010402 general chemistry
Anti-Bacterial Agents/pharmacology
Microbiology
Silver/pharmacology
Immune system
Phagocytosis
Escherichia coli
medicine
Animals
Dendritic Cells
0104 chemical sciences
chemistry
Zdroj: Nanomedicine : nanotechnology biology and medicine
Nanomedicine, Vol. 13, No 1 (2017) pp. 11-22
ISSN: 1549-9634
Popis: The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
Databáze: OpenAIRE
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